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Where to turn for disinterested scientific knowledge and insight?

Posted by Henry Bauer on 2018/02/11

The “vicious cycle of wrong knowledge” illustrates the dilemma we face nowadays: Where to turn for disinterested scientific knowledge and insight?

In centuries past in the intellectual West, religious authorities had offered unquestionable truth. In many parts of the world, religious authorities or political authorities still do. But in relatively emancipated, socially and politically open societies, the dilemma is inescapable. We accept that religion doesn’t have final answers on everything about the natural world, even if we accept the value of religious teachings about how we should behave as human beings. Science, it seemed, knew what religion didn’t, about the age of the Earth, about the evolution of living things, about all sorts of physical, material things. So “science” became the place to turn for reliable knowledge. We entered the Age of Science (Knight, 1983). But we (most of us) recognize that scientific knowledge cannot be absolutely and finally true because, ultimately, it rests on experience, on induction from observations, which can never be a complete reflection of the natural world; there remain always the known unknown and the unknown unknown.

Nevertheless, for practical purposes we want to be guided by the best current understanding that science can afford. The problem becomes, how to glean the best current understanding that science can offer?

Society’s knee-jerk response is to consult the scientific community: scientific associations, lauded scientists, government agencies, scientific literature. What society hears, however, is not a disinterested analysis or filtering of what those sources say, because all of them conform to whatever the contemporary “scientific consensus” happens to be. And, as earlier discussed (Dangerous knowledge II: Wrong knowledge about the history of science), that consensus is inevitably fallible, albeit the conventional wisdom is not on guard against that, largely because of misconceptions stemming from an holistic ignorance of the history of science.

The crux of the problem is that scientific knowledge and ideas that do not conform to the scientific consensus are essentially invisible in the public sphere. In any case, society has no mechanism for ensuring that what the scientific consensus holds at any given time is the most faithful, authoritative reflection of the available evidence and its logical interpretation. That represents clear and present danger as “science” is increasingly turned to for advice on public policies, in an environment replete with claims of truth from many sides, people claiming to speak for religion or for science, or organizations claiming to do so, including sophisticated advertisements by commercial and political groups.

In less politically partisan times, Congress and the administration had the benefit of the Office of Technological Assessment (OTA), founded in 1972 to provide policy makers with advice, as objective and up-to-date as possible, about technical issues; but OTA was disbanded in 1995 for reasons of partisan politics, and no substitute has been established. Society needs badly some authoritative, disinterested, non-partisan mechanism for analyzing, filtering, and interpreting scientific claims.

The only candidate so far on offer for that task is a Science Court, apparently first mooted half a century ago by Arthur Kantrowitz (1967) in the form of an “institute for scientific judgment”, soon named by others as a Science Court (Cavicchi 1993; Field 1993; Mazur 1993; Task Force 1993). Such a Court’s sole mission would be to assess the validity of conflicting contemporary scientific and technical claims and advice.

The need for such a Court is most obvious in the context of impassioned controversy in the public arena where political and ideological interests confuse and obfuscate the purely technical points, as for instance nowadays over global warming (A politically liberal global-warming skeptic?). Accordingly, a Science Court would need complete independence, for which the best available appropriate model is the United States Supreme Court. Indeed, perhaps a Science Court could be managed and supervised by the Supreme Court.

Many knotty issue beside independence present themselves in considering how a Science Court might function: choice of judges or panels or juries; choice of issues to take on; possibilities for appealing findings. For an extended discussion of such matters, see chapter 12 of Science Is Not What You Think and further sources given there. But the salient point is this:

Society needs but lacks an authoritative, disinterested, non-partisan mechanism for adjudicating conflicting scientific advice. A Science Court seems the only conceivable possibility.


Jon R. Cavicchi, “The Science Court: A Bibliography”, RISK — Issues in Health and Safety, 4 [1993] 171–8.

Thomas G. Field, Jr., “The Science Court Is Dead; Long Live the Science Court!” RISK — Issues in Health and Safety, 4 [1993] 95–100.

Arthur Kantrowitz, “Proposal for an Institution for Scientific Judgment”, Science,
156 [1967] 763–4.

David Knight, The Age of Science, Basil Blackwell, 1986.

Allan Mazur, “The Science Court: Reminiscence and Retrospective”, RISK — Issues in Health and Safety, 4 [1993] 161–70.

Task Force of the Presidential Advisory Group on Anticipated Advances in Science and Technology, “The Science Court Experiment: An Interim Report”, RISK — Issues in Health and Safety, 4 [1993] 179–88


Posted in consensus, legal considerations, media flaws, politics and science, science is not truth, science policy, scientific culture, unwarranted dogmatism in science | Tagged: | 2 Comments »

Fog Facts: Side effects and re-positioning of drugs

Posted by Henry Bauer on 2017/11/23

Fog Facts: things that are known and yet not known —
[not known to the conventional wisdom, the general public, the media
but known to those (few) who are genuinely informed about the subject]

For that delightful term, Fog Facts, I’m grateful to Larry Beinhart who introduced me to it in his novel “The Librarian”. There it’s used in connection with political matters, but it’s entirely appropriate for the disconnect between “what everyone knows” about blood pressure, cholesterol, prescription drugs, and things of that ilk, and what the actual facts are in the technical literature.

For example, the popular shibboleth is that drug companies spend hundreds of millions of dollars in the development of a new drug, and that’s why they need to make such large profits to plough back into research. The truth of the matter is that most new drugs originate in academic research, conducted to a great extent at public expense; and drug companies spend more on advertising and marketing than they do on research. All that is known to anyone who cares to read material other than what the drug-company ads say and what the news media disseminate; and yet it’s not known because too few people read the right things, even books by former editors of medical journals and academic researchers at leading universities and published by mainstream publishers; see “What’s wrong with modern medicine”.

When it comes to drug “development”, the facts are all hidden in plain view. There’s even a whole journal about it, Nature Reviews — Drug Discovery, that began publication in 2002. I came to learn about this because Josh Nicholson had alerted me to an article in that journal, “Drug repositioning: identifying and developing new uses for existing drugs” (by Ted T. Ashburn and Karl B. Thor, 3 [2004] 673-82). I had never heard of “drug repositioning”. What could it mean?

Well, it means finding new uses for old drugs. And the basic reason for doing so is that it’s much easier and more profitable than trying to design or discover a new drug, because old drugs have already been approved as safe, and it’s already known how to manufacture them.

What seems obvious, however — albeit only as a Fog Fact — is that the very success of repositioning drugs should be a red flag warning against the drug-based medicine or drug-first medicine or drug-besotted medicine that has become standard practice in the United States. The rationale for prescribing a drug is that it will fix what needs attending to without seriously and adversely affecting anything else, in other words that there are no serious “side” effects. But repositioning a drug shows that it has a comparably powerful effect on something other than its original target. In other words, “side” effects may be as powerful and significant as the originally intended effect. Ashburn and Thor give a number of examples:

Cymbalta was originally prescribed to treat depression, anxiety, diabetic peripheral neuropathy, and fibromyalgia (all at about the same dosage, which might cause one to wonder how many different mechanisms or systems are actually being affected besides the intended one). The listed side effects do not include anything about urination, yet the drug has been repositioned as Duloxetine SUI to treat “stress urinary incontinence (SUI), a condition characterized by episodic loss of urine associated with sharp increases in intra-abdominal pressure (for example, when a person laughs, coughs or sneezes)”; and “Lilly is currently anticipating worldwide sales of Duloxetine SUI to approach US $800 million within four years of launch”.

Dapoxetine was not a success for analgesia or against depression, but came into its own to treat premature ejaculation.

Thalidomide was originally marketed to treat morning sickness, but it produced limb defects in babies. Later it was found effective against “erythema nodosum laprosum (ENL), an agonizing inflammatory condition of leprosy”. Moreover, since the birth defects may have been associated with blocking development of blood vessels, thalidomide might work against cancer; and indeed “Celgene recorded 2002 sales of US $119 million for Thalomid, 92% of which came from off-label use of the drug in treating cancer, primarily multiple myeloma . . . . Sales reached US $224 million in 2003 . . . . The lesson from the thalidomide story is that no drug is ever understood completely, and repositioning, no matter   how unlikely, often remains a possibility” [emphasis added: once the FDA has approved drug A to treat condition B, individual doctors are allowed to prescribe it for other conditions as well, although drug companies are not allowed to advertise it for those other uses. That legal restriction is far from always honored, as demonstrated by the dozens of settlements paid by drug companies for breaking the law.]

Perhaps the prize for repositioning (so far) goes to Pfizer, which turned sildenafil, an unsuccessful treatment for angina, into Viagra, a very successful treatment for “erectile dysfunction”: “By 2003, sildenafil had annual sales of US $1.88 billion and nearly 8 million men were taking sildenafil in the United States alone”.

At any rate, Ashburn and Thor could not be more clear: The whole principle behind repositioning is that it’s more profitable to see what existing drugs might do than to look for what might be biologically speaking the best treatment for a given ailment. So anti-depressants get approved and prescribed against smoking, premenstrual dysphoria, or obesity; a Parkinson’s drug and a hypertension drug are prescribed for ADHD; an anti-anxiety medication is prescribed for irritable bowel syndrome; Alzheimer’s, whose etiology is not understood, gets treated with Reminyl which, as Nivalin, (generic galantamine) is also supposed to treat polio and paralysis. Celebrex, a VIOXX-type anti-arthritic, can be prescribed against breast and colon cancer; treatment of enlarged prostate is by the same drug used to combat hair loss; the infamous “morning after” pill for pregnancy termination can treat “psychotic major depression”; Raloxifene to treat breast and prostate cancer is magically able also to treat osteoporosis.

And so on and so forth. This whole business of drug repositioning exposes the fallacy of the concept that it is possible to find “a silver bullet”, a chemical substance that can be introduced into the human body to accomplish just one desired thing. That concept ought to be recognized as absurd a priori, since we know that human physiology is an interlocking network of signals, feedback, attempted homeostasis, defenses against intruders.

It is one thing to use, for brief periods of time, toxins that can help the body clear infections — sulfa drugs, antibiotics. It is quite another conceit and ill-founded hubris to administer powerful chemicals to decrease blood pressure, lower cholesterol, and the like, in other words, to attempt to alter interlocking self-regulating systems as though one single aspect of them could be altered without doing God-only-knows-what-else elsewhere.

The editorial in the first issue (January 2002) of Nature Reviews Drug Discovery was actually clear about this: “drugs need to work in whole, living systems”.

But that editorial also gave the reason for the present-day emphasis on medicine by drugs: “Even with vastly increased R & D spending, the top 20 pharmaceutical companies still churn out only around 20 drugs per year between them, far short of the 4-5 new drugs that analysts say they each need to produce to justify their discovery and development costs”.

And the editorial also mentions one of the deleterious “side” effects of the rush to introduce new drugs: “off-target effects . . . have led to the vastly increased number of costly late-stage failures seen in recent years (approximately half the withdrawals in the past 20 years have occurred since 1997)” — “off-target effects” being a synonym for “side” effects.

It’s not only that new drugs are being rushed to market. As a number of people have pointed out, drug companies also create their own markets by inventing diseases like attention-deficit disorder, erectile dysfunction, generalized anxiety disorder, and so on and on. Any deviation of behavior from what might naively be described as “normal” offers the opportunity to discover a new disease and to re-position a drug.

The ability of drug companies to sell drugs for new diseases is helped by the common misconception about “risk factors”. Medication against hypertension or high cholesterol, for example, is based on the presumption that both those raise the risk of heart attack, stroke, and other undesirable contingencies because both are “risk factors” for such contingencies. But “risk factor” describes only an observed association, a correlation, not an identified causation. Correlation never proves causation. “Treating” hypertension or high cholesterol makes sense only if those things are causes, and they have not been shown to be that. On the other hand, lifelong ingestion of drugs is certainly known to have potentially dangerous consequences.

Modern drug-based, really drug-obsessed medical practice is as misguided as “Seeking Immortality”.

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Vaccines: The good, the bad, and the ugly

Posted by Henry Bauer on 2017/05/21

Only in recent years have I begun to wonder whether there are reasons not to follow official recommendations about vaccination. In the 1930s, I had the then-usual vaccinations, including (in Austria, perhaps Europe) against smallpox. A few others in later years when I traveled quite a bit.

But the Andrew Wakefield affair *, and the introduction of Gardasil **, showed me that official sources had become as untrustworethy about vaccines as they have become about prescription drugs.

It seems that Big Pharma had just about run out of new diseases to invent against which to create drugs and had turned to snake-oil-marketing of vaccines. We are told, for example, that 1 in 3 people will experience shingles in their lifetime and should get vaccinated against it. Have one in three of your aged friends ever had shingles? Not among my family and friends. One of my buddies got himself vaccinated, and came down with shingles a couple of weeks later. His physician asserted that the attack would have been more severe if he hadn’t been vaccinated — no need for a control experiment, or any need to doubt official claims.

So it’s remarkable that the Swedish Government has resisted attempts to make vaccinations compulsory (“Sweden bans mandatory vaccinations over ‘serious health concerns’” by Baxter Dmitry, 12 May 2017).

That article includes extracts from an interview of Robert F. Kennedy, Jr., on the Tucker Carlson Show, which included such tidbits as the continued presence of thimerosal (organic mercury compound) in many vaccines including the seasonal flu vaccines that everyone is urged to get; and the huge increase in number of things against which vaccination is being recommended:

“I got three vaccines and I was fully compliant. I’m 63 years old. My children got 69 doses of 16 vaccines to be compliant. And a lot of these vaccines aren’t even for communicable diseases. Like Hepatitis B, which comes from unprotected sex, or using or sharing needles – why do we give that to a child on the first day of their life? And it was loaded with mercury.”



“Autism and Vaccines: Can there be a final unequivocal answer?”
      “YES: Thimerosal CAN induce autism”

** See “Gardasil and Cervarix: Vaccination insanity” and many other posts recovered with SEARCH for “Gardasil” on my blogs: and

Posted in fraud in medicine, legal considerations, medical practices, politics and science, prescription drugs, science is not truth, science policy, unwarranted dogmatism in science | Tagged: | 1 Comment »

Political Correctness in Science

Posted by Henry Bauer on 2017/03/06

Supposedly, science investigates via the scientific method: testing the validity of hunches (hypotheses) against reality and allowing reality to establish beliefs, thereby discarding disproved pre-judgments, hunches, prejudices, biases. Scientific theories. are determined by facts, evidence.   Science is empirical, pragmatic; it does not accept beliefs on authority or from tradition.

Historians, philosophers, sociologists, scholars of Science & Technology Studies have long recognized that this view of science is mythical (i), but it continues to be taught in schools and in social-science texts and it is the conventional wisdom found in the media and in public discourse generally. A corollary of the misconception that scientific theories have been successfully tested against reality is the widespread belief that what science says, what the contemporary scientific consensus is, can safely be accepted as truth for all practical purposes.

So it seems incongruous, paradoxical, that large numbers of scientists should disagree violently, on any given issue, over what science really says. Yet that is the case on a seemingly increasing range of topics (ii), some of them of great public import, for instance whether HIV causes AIDS (iii) or whether human-generated carbon dioxide is the prime cause of global warming and climate change. On those latter matters as well as some others, the difference of opinion within the scientific community parallels political views: left-leaning (“liberal”) opinion regards it as unquestionably true that HIV causes AIDS and that human-generated carbon dioxide is the prime cause of global warming and climate change, whereas right-leaning (“conservative”) opinion denies that those assertions constitute “settled science” or have been proved beyond doubt. Those who harbor these “conservative” views are often labeled “denialists”; it is not to be countenanced that politically liberal individuals should be global warming skeptics (iv).

In other words, it is politically incorrect to doubt that HIV causes AIDS or that human-generated carbon dioxide is the prime cause of global warming. It requires no more than cursory observation of public discourse to recognize this pervasive phenomenon. Governments and Nobel-Prize committees illustrate that those beliefs are officially acted on as though they were established truths. One cadre of mainstream scientists even wants criminal charges laid (v) against those who question that global warming is caused primarily by human-generated carbon dioxide. So political correctness is present within the scientific community in the USA.

I’m of a sufficient age to be able to testify that half a century ago it would not have occurred to any researchers in a democratic society to urge the government to prosecute for criminal conspiracy other researchers who disagreed with them. Declaring certain scientific research programs as politically incorrect and therefore substantively without merit, and persecuting those who perpetrated such research, characterized totalitarian regimes, not free societies. Stalin’s Soviet Union declared wrong the rest of the world’s understanding of genetics and imprisoned exponents of it; it also declared wrong the rest of the world’s understanding of chemical bonding and quantum mechanics. Nazism’s Deutsche Physik banned relativity and other “Jewish” science.


Political correctness holds that HIV causes AIDS and that human-generated carbon dioxide is the prime cause of global warming. Those beliefs also characterize left-leaning opinion. Why is political correctness a left-wing phenomenon?

In contemporary usage, political correctness means “marked by or adhering to a typically progressive orthodoxy on issues involving especially ethnicity, gender, sexual orientation, or ecology” (vi) or “conforming to a belief that language and practices which could offend political sensibilities (as in matters of sex or race) should be eliminated” (vii), evidently “progressive” or “liberal” or Left-ish views. But those descriptions fail to capture the degree of fanatical dogmatism that can lead practicing scientists to urge that those of differing views be criminally prosecuted; political correctness includes the wish to control what everyone believes.

Thus political correctness has been appropriately called “liberal fascism”, which also reveals why it is a phenomenon of the ultra-extreme Left. Attempted control of beliefs and corresponding behavior is openly proclaimed, unashamedly, by the extreme Right; it is called, and calls itself, fascism, Nazism, and needs no other name. But the Left, the “liberals”, claim to stand for and to support individual freedom of belief and speech; so a name is needed for the phenomenon by which proclamations of liberal ideals are coupled with attempts to enforce adherence to particular beliefs and social norms. Political correctness is the hypocrisy of self-proclaimed liberals functioning as authoritarian fascists.

That hypocrisy pervades political correctness, I was able to observe at first hand during my years in academic administration. People say things they don’t mean, and that they know everyone knows they don’t mean, and no one dares point to the absence of the Emperor’s clothes. For instance, the Pooh-Bahs assert that affirmative action means goals and not quotas, even as hiring practices and incentives demonstrate that they are quotas. For innumerable examples gathered over the years, see the newsletter I edited from 1993 until my retirement at the end of 1999 (viii).


Science had represented for a long time the virtues associated with honest study of reality. Around the 1930s and 1940s, sociologist Robert Merton could describe the norms evidently governing scientific activity as communal sharing of universally valid observations and conclusions obtained by disinterested people deploying organized skepticism. That description does not accommodate researchers urging criminal prosecution of peers who disagree with them about evidence or conclusions. It does not accommodate researchers lobbying publishers to withdraw articles accepted for publication following normal review; and those norms do not describe the now prevalent circumstances in which one viewpoint suppresses others through refusal to allow publication or participation in scientific meetings (ix).

Science, in other words, is not at all what it used to be, and it is not what the popular view of it is, that common view having been based on what scientific activity used to be. It has not yet been widely recognized, how drastically science has changed since about the middle of the 20th century (x). Among the clues indicative of those changes are the spate of books since the 1980s that describe intense self-interested competition in science (xi) and the increasing frequency of fraud, again beginning about in the 1980s, that led to establishment of the federal Office of Research Integrity. That political correctness has surfaced within the scientific community is another illustration of how radically different are the circumstances of scientific activity now compared to a century ago and by contrast to the outdated conventional wisdom about science.

Political correctness began to pervade society as a whole during the same years as science was undergoing drastic change. The roots of political correctness in society at large may be traceable to the rebellious students of the 1960s, but the hegemony of their ideals in the form of political correctness became obvious only in the 1980s, when the term “political correctness” came into common usage:

The origin of the phrase in modern times is generally credited to gallows humor among Communists in the Stalin era (xii):

“Comrade, your statement is factually incorrect.”
“Yes, it is. But it is politically correct.”

That political correctness is in contemporary times a Left-ish phenomenon is therefore true to its modern origin.

How seriously political correctness corrupts science should be obvious, since it more than breaks all the traditional norms. Those norms are often summarized as universalism, communalism, disinterestedness, skepticism — taking for granted as well simple honesty and absence of hypocrisy. Nowadays what was taken for granted no longer applies. It is simply dishonest to assert that something has been proven beyond doubt when strong contrary evidence exists that is taken seriously by competent researchers. One cannot, of course, look into the minds of those who assert certainty where there is none (xiii), but among possible explanations, hypocrisy may be the least culpable.

Science cannot be isolated from the rest of society, so the incursion of political correctness into science is understandable. Moreover, what used to be the supposedly isolated ivory tower of academe is nowadays the very epicenter where political correctness breeds and from where it spreads. Whatever the causes may be, however, it is important to recognize how science has changed and that it can be corrupted by the same influences as the rest of society.


i        Henry H. Bauer, Scientific Literacy and Myth of the Scientific Method, University of Illinois Press 1992;

ii       Henry H. Bauer, Dogmatism   in Science and Medicine: How Dominant Theories Monopolize Research and Stifle the Search for Truth, McFarland 2012.

iii      Henry H. Bauer, The Origin, Persistence and Failings of HIV/AIDS Theory, McFarland 2007.

iv      Henry H. Bauer, “A politically liberal global-warming skeptic?”, 2012/11/25;

v       Letter to President Obama, Attorney General Lynch, and OSTP Director Holdren, 1 September 2015;
The original pdf posted in 2003 at is no longer there. The Wayback Machine says, “The letter that was inadvertently posted on this web site has been removed. It was decided more than two years ago that the Institute of Global Environment and Society (IGES) would be dissolved when the projects then undertaken by IGES would be completed. All research projects by IGES were completed in July 2015, and the IGES web site is in the process of being decommissioned”.
As of March 2017, however, a Google search for “Institute of Global Environment and Society” led to a website with that header, albeit augmented by “COLA”: accessed 4 March 2017. Right-leaning Internet sources offer insight into this seeming mystery: and, both accessed 4 March 2017.

vi (accessed 4 March 2017).

vii (accessed 4 March 2017).


ix      Ref. ii, especially chapter 3.

x       Henry H. Bauer, “Three stages of modern science”, Journal of Scientific Exploration, 27 (2013) 505-13;

xi      Natalie Angier, Natural Obsessions: The Search for the Oncogene, Houghton Mifflin 1987; David H. Clark, The Quest for SS433, Viking 1985; Sheldon Glashow with Ben Bova, Interactions: A Journey through the Mind of a Particle Physicist and the Matter of the World, Warner 1988; Jeff Goldberg Anatomy of a Scientific Discovery, Bantam 1988; Stephen S. Hall, Invisible Frontiers: The Race to Synthesize a Human Gene, Atlantic Monthly Press 1987; Robert M. Hazen, The Breakthrough: The Race for the Superconductor, Summit 1988; David L. Hull, Science as a Process: An Evolutionary Account of the Social and Conceptual Development of Science, University of Chicago Press 1988; Robert Kanigel, Apprentice to Genius: The Making of a Scientific Dynasty, Macmillan 1986; Charles E. Levinthal,. Messengers of Paradise: Opiates and the Brain, Anchor/Doubleday 1988; Roger Lewin, Bones of Contention: Controversies in the Search for Human Origins, Simon and Schuster 1987; Ed Regis, Who Got Einstein’s Office: Eccentricity and Genius at the Institute for Advanced Study, Addison-Wesley 1987; Bruce Schechter, The Path of No Resistance: The Story of the Revolution in Superconductivity, Touchstone (Simon and Schuster) 1990; Solomon H. Snyder, Brainstorming: The Science and Politics of Opiate Research, Harvard University Press 1989; Gary Taubes, Nobel Dreams: Power, Deceit, and the Ultimate Experiment, Random House 1986; Robert Teitelman, Gene Dreams: Wall Street, Academia, and the Rise of Biotechnology, Basic Books 1989; Nicholas Wade, The Nobel Duel: Two Scientists’ 21-Year Race to Win the World’s Most Coveted Research Prize, Doubleday 1981.

xii     Jon Miltimore, “The historical origin of ‘political correctness’”, 5 December 2016,; Angelo M. Codevilla, “The rise of political correctness”, Claremont Review of Books, Fall 2016, pp. 37-43;

xiii    Henry H. Bauer , “Shamans of Scientism: Conjuring certainty where there is none”, Journal of Scientific Exploration, 28 (2014) 491-504.


Posted in legal considerations, media flaws, politics and science, science is not truth, scientific culture, scientists are human, the scientific method, unwarranted dogmatism in science | Tagged: | Leave a Comment »

All vaccines are not the same; some are worse than useless

Posted by Henry Bauer on 2015/07/02

I am not among those who question the value of all vaccines on principle. I don’t doubt the value of vaccines in controlling smallpox, measles, polio. I do question the use of adjuvants and preservatives in vaccines, and I do think it makes sense to vaccinate babies against measles and the rest in single shots administered over a period of time instead of all at once in multiple vaccines.

But it gets difficult not to over-react as Big Pharma concentrates on generating vaccines that do more harm than any good that has ever been proven.

It seems that Big Pharma has been running out of new diseases to invent (see Moynihan & Cassels, Selling Sickness: How the World’s Biggest Pharmaceutical Companies Are Turning Us All Into Patients and other works listed in “What’s Wrong with Present-Day Medicine”) and has been turning increasingly to inventing vaccines supposed to guard against old or new infections.

The expected but not forthcoming “swine flu” epidemic led to rapid invention and marketing of a vaccine that turned out to have nasty “side” effects, for example, “How a swine flu shot led to narcolepsy”.

Gardasil and Cervarix, anti-HPV vaccines claimed to prevent cervical cancer, are a scandalous illustration; see for example “Merck Dr. Exposes Gardasil as Ineffective, Deadly, Very Profitable”  and related links. The only suggestion that HPV causes cervical cancer — or rather, that 4 out of four or five times that number of strains of HPV cause cervical cancer — comes from a correlation: those strains have often been found in women who have cervical cancer.

But correlations never, never, never prove causation, no matter that too many medical “experts” ignore this well established, long established fact.

I’ve become all too cynical about Big Pharma, lack of regulation, conflicts of interest, and the like. Yet I was taken aback to find that the National Institutes of Health profit from royalties from sales of Gardasil, and that there are exemptions to the Freedom of Information Act that enable them to hide that fact and the amounts involved.

Posted in conflicts of interest, fraud in medicine, funding research, legal considerations, medical practices, politics and science, prescription drugs | Tagged: , , | 7 Comments »

NOVA’s vaccine propaganda: Media coverage

Posted by Henry Bauer on 2014/09/18

NOVA’s presentation on vaccination  was obviously one-sided, and a few observers noted as much:

Verne Gay at Newsday recognized  the program to be “designed as an ironclad, insistent, well-reported film that, in the very nicest way possible, tells those who have decided not to vaccinate their children that they are — essentially — blithering idiots. There is no debate, or should be no debate, or if there is a debate, those doing the debating have spent way too much time on the Internet. . . . like an industry film in support of a product”.

Dave Walker at the Times-Picayune allowed the program’s producer, Sonya Pemberton, to confess her bias. She described herself as “from a medical family” and rather immodestly as “scientifically educated”, whatever that might mean substantively. In practice, of course, it’s spin intended to inveigle her audience that she knows what’s science and what isn’t. She was “trying to take people on this journey so that they can come to the conclusions that the science clearly supports”, in other words not presenting pro- and con- but only the one side. As Walker observes, “That point of view will cause some viewers to write off Pemberton’s journey before it starts”; though I would put it that it should cause all viewers to write off Pemberton’s journey.

Paula Apsell, NOVA’s senior executive producer, was fully in favor of making propaganda rather than a documentary: “to present the scientific facts to people in a convincing way . . . . we’re all going to be very curious as to how the ‘anti-vaxxers,’ as they are called, the people who really don’t accept vaccination, react to this film”. Evidently like Pemberton, Apsell thinks “vaccination” is unproblematically good always and everywhere, when in fact any halfway “scientifically educated” person — or anyone with common sense who thinks about it even briefly — can recognize that vaccination against an infectious disease to guard against epidemics could be an entirely different matter than vaccination against something endemic in the population, let alone against something not yet proven to cause any harm at all.

I was curious about the term “anti-vaxxer”, which was new to me. Through Google I was able to trace it to no earlier than 2009. Perhaps it is not coincidental that the HPV vaccine Gardasil was approved by the Food and Drug Administration in 2006, and within a few years some severe adverse reactions were being reported by parents. Perhaps as a result of public concerns over parental rights as well as adverse reactions, Merck claimed to be suspending its lobbying to have vaccination with Gardasil made compulsory for school attendance [1].
That the reports of serious harm from Gardasil and Cervarix have not faded away is illustrated by the 2013 decision in Japan to suspend vaccination “because several adverse reactions to the medicines have been reported” [2]. In Britain, reports of adverse events were allegedly suppressed [3].

There is no need to speculate about why it was in Japan that official public notice was taken of the fact that serious adverse events from Gardasil and Cervarix are far more frequent than with other vaccines: None of the Big Pharma companies  are Japanese-owned. This is not a conspiracy theory: “conspiracy” implies secrecy, and the misdeeds of Big Pharma have been described and documented in dozens of books and articles.
The same non-conspiracy fact explains why the mass media in the USA did not disseminate this action by Japanese authorities.

The Japanese findings also answer a question that the NOVA program posed but did not answer: Why there has been an unusual amount of controversy about Gardasil and Cervarix by comparison to other vaccines? It’s because of the much greater frequency and considerably greater seriousness of adverse reactions to those vaccines.

As with drugs, a largely unrecognized danger is that there exists no systematic monitoring of adverse events once a drug, a medical device, or a vaccine has been approved. Physicians are not well placed to discern whether an adverse reaction results from a drug or from some other condition, typically the ailment for which the drug is prescribed in the first place. A study comparing systematic monitoring with spontaneous reporting found that under-reporting was as high as 98% [4]. In other words, adverse events might be 50 times as frequent as official data reveal.

At any rate, it seems not unlikely that the term “anti-vaxxer” was introduced by determined supporters of mainstream practices as a way of maligning and discrediting those who were bringing to public attention the reports of such serious consequences of vaccination by Gardasil or Cervarix as blindness, convulsions, deafness, paralysis.

Back to media coverage of the NOVA puff-piece:
While a few observers like Verne Gay at Newsday and Dave Walker at the Times-Picayune recognized how one-sided a piece of propaganda this is, others were taken in, or simply too lazy or thoughtless to see it. According to the Pittsburgh Post-Gazette, it was “balanced” and concluding “gently” that vaccines are “safe and effective”, “without dodging or downplaying the mild, occasional serious and rare deadly risks vaccines can pose”. Chris Mooney, whose own biases are worn on his sleeve [5], was gullible and enthusiastic: “If you care about science, it’s something you should watch” is a remarkable and reprehensible comment about a program that avoided any discussion of the scientific issues and argued purely from authority. Mooney was also taken in by the program’s featuring of a “decision psychologist”, citing “our faulty risk perceptions around vaccines”.
I would put this to Mooney, Sonya Pemberton, and other groupies of universal vaccination: The NOVA program mentioned that officially required vaccinations for attending school vary from State to State within the USA, demonstrating that they are not based on science.


[1] Linda A. Johnson, Merck suspends lobbying for vaccine
[2] Cervix vaccine issues trigger health noticeJapan withdraws HPV Vaccine recommendation for girlsJapan’s suspension of recommendation for Gardasil & Cervarix HPV Vaccines for women – Caused by large numbers of unexplained serious adverse reactionsJapan and the HPV Vaccine ControversyJapan: International medical researchers issue warning about HPV Vaccine side effects
[3] UK Drug Safety Agency falsified Vaccine Safety Data for 6 million
[4] A. P. Fletcher, “Spontaneous adverse drug reaction reporting vs event monitoring: a comparison”, Journal of the Royal Society of Medicine, 84 (1991) 341-4
[5] Henry H. Bauer, “Not even wrong about science and politics”, Journal of Scientific Exploration, 27 (2013) 540-52 — essay review of Mooney, The Republican War on Science and Berezow & Campbell, Science Left Behind: Feel-Good Fallacies and the Rise of the Anti-Scientific Left

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Big Pharma beware: The comedians are on to you

Posted by Henry Bauer on 2014/09/17

Authoritarian regimes, and politicians in general for that matter, are terrified of being made fun of.  In present-day Egypt, for example, the local equivalent of The Daily Show is being persecuted. So it is a very promising development that our very own Daily Show last night, Tuesday 16 September, had a segment featuring  Peter Gøtzsche describing the drug companies as organized crime, as in his book, Deadly Medicines and Organised Crime: How Big Pharma Has Corrupted Healthcare.

It was mentioned that Pharma’s propaganda for painkillers like oxycontin and percocet is misleading and damaging, and some of Pharma’s ads were satirized.

I would like to think that the clip was quite genuine, that showed a Pfizer person — perhaps a security guard? — waving away the Daily Show correspondent and the camera.

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Anti-obesity drug-peddling (Anti-obesity fuss III)

Posted by Henry Bauer on 2014/09/04

There is no epidemic of obesity: there is only an epidemic of eating unhealthily and too much (Anti-obesity fuss part I). However, official reports (Anti-obesity fuss part II) and professional organizations abet Big Pharma’s re-definition of lifestyle issues as conditions to be treated medically, including by drugs and even surgery. As is all too typical, the risks associated with drugs fail to be emphasized, and there is no demonstration that the possible benefits of medical intervention exceed those risks.

“In carefully selected patients, appropriate drugs can augment LCDs [low-calorie diets], physical activity, and behavior therapy in weight loss. Weight loss drugs that have been approved by the FDA for long-term use can be useful adjuncts to dietary therapy and physical activity for some patients with a BMI of ≥ 30 with no concomitant risk factors or diseases, and for patients with a BMI of ≥ 27 with concomitant risk factors or diseases. The risk factors and diseases considered important enough to warrant pharmacotherapy at a BMI of 27 to 29.9 are hypertension, dyslipidemia, CHD, type 2 diabetes, and sleep apnea. Continual assessment by the physician of drug therapy for efficacy and safety is necessary” (p. xx in [1], emphases added).

All this may seem unexceptionable, yet it is dangerously misleading:

  •  In the real world of actual medical practice, patients are far from “carefully selected”, and prescriptions are written without the doctor having good evidence that the prescribing actually augments rather than replacing what should have been tried first and for some reasonable length of time, namely diet.
  •  The naming of BMI ranges where drugs are appropriate depending on “concomitant risk factors” makes no sense since that range of BMI, 27 to 29.9, is already itself such a risk: “All . . . adults . . . with a BMI of ≥25 are considered at risk for developing associated morbidities or diseases such as hypertension, high blood cholesterol, type 2 diabetes, coronary heart disease, and other diseases” (p. xii).
  • FDA-approved drugs have often had to be later withdrawn because the initial approval was unwarranted. Thus “At the present time [1998], sibutramine is available for long-term use” (p. xx), but it was withdrawn in 2010 “based on information from a recent clinical study”  showing increased incidence of heart attack and stroke.
    Why had that not shown up in pre-approval clinical trials?
    That question is rhetorical and cynical. Clinical trials submitted in support of drug approval are carefully designed and chosen to emphasize benefits and to mask deleterious “side” effects. It is normal for later studies to show more harm and less benefit [2].
    But even in 1998, the risk-to-benefit ratio did not look good. “It enhances weight loss modestly and can help facilitate weight loss maintenance” [emphases added] hardly describes something that is genuinely effective; on the other hand, “side” effects weree known to be potentially serious: “increases in blood pressure and heart rate may occur.”

In 1998, orlistat was being considered for approval, which was soon granted. Orlistat disrupts the body’s normal fat-metabolizing mechanisms in order to decrease the absorption of fat in the diet. In 2010, the Food and Drug Administration issued a warning about potentially severe liver damage from orlistat, either the prescription form (Xenical, 120 mg) or the over-the-counter[!] version (Alli, 60 mg).
Another rhetorical question: Who would have guessed that disrupting the body’s fat-metabolizing mechanisms could cause liver damage (as well as Lord knows what else)?

Our bodies are complex systems in which substances and mechanisms are shared and interact in many ways, with feedbacks and regulators. It is naïve, stupid, ignorant, to imagine that one can disrupt one reaction or mechanism without producing multiple effects; yet drug treatments are based on that mistaken assumption. Hence “side” effects are universal, and all too often they are significanty harmful. For example, the same reaction pathway that generates cholesterol also generates ubiquinone (Coenzyme Q10) which is an essential part of the body’s energy-producing reactions; therefore weakening of muscles is an inevitable “side” effect of statins (Statins: Scandalous new guidelines; Statins weaken muscles by design).

The peddling of anti-obesity drugs proceeds even as their claimed benefits are small to non-existent. It is reported that lifestyle changes alone can yield weight loss of about 10% in a year (pp. xxv, xxvi in [1]), yet the FDA’s criterion for approving anti-obesity drugs is an even smaller weight loss (p. 7 in Guidance for Industry Developing Products for Weight Management):

“In general, a product can be considered effective for weight management if after 1 year of
treatment either of the following occurs:
• The difference in mean weight loss between the active-product and placebo-treated
groups is at least 5 percent and the difference is statistically significant
• The proportion of subjects who lose greater than or equal to 5 percent of baseline body
weight in the active-product group is at least 35 percent, is approximately double the
proportion in the placebo-treated group, and the difference between groups is statistically

This trivial goal has allowed approval of drugs that turned out to be lethal. Fen-phen (fenfluramine/phentermine) damaged lungs and heart valves and yielded damages of billions of dollars to subsequent law-suits. Sibutramine, once approved for long-term use had to be withdrawn only a dozen years later (I’m reminded of the monument I saw in Strasburg in 1958: “The Thousand-Year Reich — 1933-1945”).

These drugs suppress appetite by acting on the brain’s neurotransmitters, primarily serotonin, in other words they mess with brain functioning, affecting substances that are involved in much more than appetite, for example serotonin is targeted also by anti-depressants.

Since this Guidance for Industry had been published in 2007 and labeled a “guidance document . . . distributed for comment purposes only”, I sought a later version. There is none [3]:
“The 2007 Draft Guidance for Industry Developing Products for Weight Management is the most up to date version of the guidance. Unfortunately this guidance is not final and we do not have an estimated date of when this will become final”.
These blog posts were stimulated by recent plaudits for purportedly brand-new anti-obesity drugs:
“Not a moment too soon — Why new diet drugs, Belviq and Qsymia, are just in time”.
According to this story, more than one-third of the USA population is obese and 300,000 die annually from “related complications”.

However, these “new” wonder drugs are the same thing all over again.

Belviq ((lorcaserin) “is a serotonin 2C receptor agonist indicated as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults” [emphases added].
It should only be used if diet alone hasn’t worked, and it messes up brain function, so it’s not at all surprising that its “side” effects include “potentially life-threatening serotonin syndrome . . . . confusion, Cognitive Impairment, disturbances in attention or memory . . . , Psychiatric Disorders including euphoria and dissociation, . . . depression or suicidal thoughts” [emphasis added] as well as priapism (erections lasting longer than 4 hours) [4].

Qsymia® (formerly QNEXA) goes one better than Belviq by combining two medicals, phentermine and topiramate. Phentermine is an amphetamine that was part of fen-phen: “deemed safe but was not effective in weight control without its [heart-failure-inducing] partner [fenfluramine]”.  Its new partner, topiramate, “previously FDA-approved for epilepsy. . . . is unrelated to any other drug . . . . No one really knows how topiramate works on the brain, exactly, but it seems to influence a wide range of neuropsychiatric symptoms”.
So Qsymia also messes up brain functioning — moreover in a manner that isn’t understood! — so again it’s no surprise that its “side” effects include suicidal thoughts or actions, depression, anxiety, agitation, panic attacks, insomnia, irritability, aggression, anger, violence, acting on dangerous impulses, mania . . . . As well as increased heart rate and serious eye problems, sudden decrease in vision that could bring permanent blindness (About Qsymia).

The merest hint of these possible “side” effects ought to disqualify these drugs from being used in anything other than cases of imminently life-threatening obesity. It is nothing short of absurd to suggest, let alone recommend, that over-eating should be treated with drugs that disrupt the body’s fat metabolism or the brain’s functioning.

However, the interests vested in drug-based anti-obesity measures are vast. Bureaucracies and jobs are at stake, and research careers. The decisive interest, though, comes from the drug industry. Big Pharma is fixated on blockbuster drugs, things that many people will take over long periods, hence the relentless marketing of statins, blood-pressure- and blood-sugar-lowering drugs, bone-density-increasing drugs, etc.
Big Pharma has no interest in anti-obesity drugs to treat that tiny proportion of people who might actually need them, those with hereditary (”endogenous”) obesity. Instead there are intensive advertising campaigns to convince doctors as well as the general public that drugs are an appropriate way to combat the epidemic of over-eating.

This is yet another illustration that drug companies nowadays market diseases [5] in order to sell supposed remedies. Perfectly normal conditions are “medicalized” by equating them with their extremes: that feeling low, disappointed, grieving, is essentially the same as debilitating clinical depression, say; that declining libido with increasing age is “erectile dysfunction”; that blood pressure higher than normal for twenty-year-olds constitutes “hypertension” [6] and so on and on.

[1] National Heart, Lung, and Blood Institute in cooperation with The National Institute of Diabetes and Digestive and Kidney Disease, Clinical Guidelines on the Identification , Evaluation, and Treatment of Overweight and Obesity in Adults: The Evidence Report, Publication 98-4083, September 1998, National Institutes of Health
[2] John P. A. Ioannidis, “Why most published research findings are false”, PLoS Medicine, 2 (2005) 696-701; “Contradicted and initially stronger effects in highly cited clinical research”, JAMA, 294 (2005) 218-28
[3] E-mail of 22 August 2014 from “CDER DRUG INFO” <>
[4] Belviq®, revised 08/2012
[5] Moynihan & Cassels. Selling Sickness: How the World’s Biggest Pharmaceutical Companies Are Turning Us All Into Patients, Nation Books (2005) and many others, see “What’s wrong with present-day medicine” 
[6] Henry H. Bauer, “Seeking Immortality? Challenging the drug-based medical paradigm”, Journal of Scientific Exploration, 26 (2012) 867-80

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Crime pays — if you are a drug company

Posted by Henry Bauer on 2014/03/13

In Crimes of the Drug Industry I listed 11 evils perpetrated routinely by the mainstream pharmaceutical industry (“Big Pharma”).

In the text of that blog post, I also pointed out that “companies regard the fines as a small part of the costs of doing business and they continue their illegal tactics”. Peter Gøtzsche (Deadly Medicines and Organised Crime, Radcliffe, 2013) suggests a solution like the Danish treatment of tax evasion:  penalties three times what the miscreant illegally got away with.

How huge the profits are that all the big drug companies make, predominantly through illegal marketing for off-label use, are demonstrated as they find fines of billions of dollars to be trivial compared to the profits from their illegality. During just the last 5 years, they have paid fines of up to $3 billion dollars — $3,000,000,000 — without admitting guilt or changing their behavior; see Big Pharma’s Big Fines.

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Critiques of science, medicine, academe

Posted by Henry Bauer on 2014/02/25

A request for information led me to update my bibliography of books and articles describing deficiencies and flaws in present-day science, medicine, and academe. It’s posted on my personal homepage and also here.

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