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How science changed — V. And changed academe

Posted by Henry Bauer on 2018/04/19

After WWII, lavish support for science made it a cash cow that academe used to change itself; a change abetted by the corruption of collegiate sport.

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Science began as an informal cottage industry; nowadays it is a highly organized bureaucratic behemoth that is pervasively intertwined with other sectors of human society.

Science began as a disinterested quest to understand how the world works; practical applications were an incidental though welcome byproduct. Nowadays, society values science for its byproducts more than for the truths it reveals about Nature.

Teaching institutions, colleges, universities were founded to educate (albeit sometimes indoctrinate) future generations. Nowadays much of academe has become a self-serving enterprise in which institutions seek status and prestige from what used to be incidental byproducts; research in academe now has an immediate eye out for patents and potential commercial applications, and intercollegiate sports for local enjoyment have become means of mass entertainment for lucrative revenue. A research university will have many dozens of administrators engaged in managing grant-related matters, intellectual property matters, compliance with regulations, status of research staff, and so on. Almost every university has many dozens of administrative staff engaged in managing its intercollegiate sports programs as well as coaches (whose salaries often exceed those of the university president) and assistant coaches (whose salaries are comparable to or exceed those of full professors).

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Scientific activity changed from a cottage industry quite slowly at first, and in fits and starts. Already in the 19th century science had been important in the commercial dye-stuff industry. During the First World War, the German war effort was supported by the discovery, by the chemist Fritz Haber, how to synthesize fertilizers and explosives using the nitrogen in the air. During the 1930s, medical practice began to have genuinely curative capabilities with the discovery of bacteria-killing sulfonamides. But, by and large, up to the Second World War scientific activity remained something of a cottage industry, and basic scientific research was largely an academic ivory-tower activity.

World War II demonstrated the powerful capabilities of applications of scientific understanding; not only the war-ending atomic bombs but also and earlier the sonar that was such an invaluable weapon against submarines and the radar that was invaluable to Great Britain in staving off the German Blitzkrieg bombers; as well as all sorts of developments and improvements in weaponry in techniques of communication and of navigation.

Vannevar Bush had been director of the U.S. Office of Scientific Research and Development, seeing at first hand what science could accomplish. Shortly after the end of World War II he presented the president of the United States with a report entitled Science: The Endless Frontier,  which suggested that scientific research and development could be as valuable to peacetime society as science had proved to be in warfare.

Bush’s initiative is generally credited for the subsequent enormous, unprecedented resources directed into the expansion of scientific activity. The federal support of science came in part as grants to support research activity in the form of specific proposed projects, but also in large part through scholarships and fellowships to stimulate more students to go into science as a career.

That influx of funds led to truly far-reaching changes in academe.

Traditionally, the role of universities was to provide tertiary education, preparing people for the professions. A small proportion of academe comprised so-called “research universities” where the faculty were as much concerned with extending the boundaries of scholarship and of science as they were with the education and training of students; yet the research and scholarship were designed to serve the aim of educating students to become independent professionals. However, the emphasis on scientific research and on training more scientists led eventually to the contemporary circumstances where the primary aim is determined by the demands of the research project rather than by whether the work is best suited for the students to learn how to do independent research. Graduate students came to be seen as cheap technical help rather than as apprentices to be nurtured; science faculty among themselves could be heard referring to the graduate students they were mentoring as “pairs of hands”. In earlier days, prospective graduate students in the sciences would choose their mentors to fit with the students’ specific research interests; nowadays graduate students in the sciences sign on to mentors who have the research grants to support them and they work as cogs in the mentor’s long-term research program [1].

The overt aim of supporting and enhancing science had the corollary effect, no doubt unforeseen and unintended, of making science more prestigious than other intellectual fields within colleges and universities. In time, that tempted some of those other fields to distort themselves in trying to mimic science and gain comparable status and prestige thereby. And not only intellectual prestige: science (and engineering and medical) faculty had higher salaries than faculty in the humanities and the social sciences, and moreover scientists could augment their academic ”9-month” salaries with an extra 20-30% from their research grants as summer-time stipends.

In the humanities, for example — philosophy, history, to some degree psychology — scholarship traditionally focused on critical analysis of traditional classical insights gained by earlier scholars, with comparatively little expectation that entirely novel, ground-breaking insights could be attained. Scholars in the humanities would occasionally publish critiques and analyses and perhaps eventually scholarly monographs. By contrast, in the sciences the emphasis was on novelty, on going beyond what was already known. As other parts of academe developed the ambition to be as well-supported fiscally and thereby as highly regarded as the sciences, they also came to emphasize originality and publication. Graduate students working towards doctoral degrees in history or psychology or sociology are nowadays supposed to generate stuff that deserves publication, often as a monograph. The sciences have become an inappropriate role model for other intellectual disciplines.

The pots of gold available for science-related activities also tempted whole institutions, four-year colleges and teachers’ colleges in particular, to seek prestige and status by transforming themselves into “research” universities. By hiring scientists, grants could be obtained whose amounts were calculated not only to cover the actual costs of the research but also “overhead” costs to reimburse the whole institution for the use of its infrastructure pertinent to the research (“indirect costs” became a popular euphemism for “overhead”). Those indirect costs could be as high as a 50% surcharge on the actual costs of research, and that provided a pool of money that upper-level administrators could draw on for all sorts of things. In the 1940s, the United States had 107 doctorate-granting research universities; by 1950–54 there were 142, by 1960–64 there were 208, and by 1970–74 the number had grown to 307 [2]; since then the rate of growth has been much less, with a count of 334 in 2016 [3 ].

 

The influx of science-related money may have stimulated academe to change in inappropriate and undesirable ways, but science cannot be held responsible for all of today’s ills of academe. Like science, like sports, like so much else, academe has been corrupted by the love of money. One of the most serious consequences is the progressive elimination of tenure-track faculty, replaced by teachers on fixed-term contracts. Academic freedom cannot exist in the absence of tenure, and genuine freedom of thought, expression, and criticism cannot exist in the absence of academic freedom.

Perhaps the most fundamental problem is that both academe and science both should be venues for unfettered truth-seeking activities. But truth-seeking is inevitably subversive, and it is never supported for its own sake by the powers that be. The corruption and distortion of science and academe make it easier for non-truths to spread, which is dangerous for the long-term health of society.

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[1]    Now-graduated Jorge Cham has described life as a graduate student by means of comic strips: see Sara Coelho, “Piled Higher and Deeper: The everyday life of a grad student”, Science, 323 (2009) 1668–9.
[2]    A Century of Doctorates: Data Analyses of Growth and Change, National Academies Press, 1978.
[3]    According to the Carnegie Classification of Institutions of Higher Education

 

 

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Categories: funding research, science policy, scientific culture
Tags: science changed academe,corruption of academe

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Denialism and pseudo-science

Posted by Henry Bauer on 2018/03/31

Nowadays, questioning whether HIV causes AIDS, or whether carbon dioxide causes global warming, is often deplored and attacked as “denialism” or pseudo-science. Yet questioning those theories is perfectly good, normal science.

Science is many things, including a human activity, an institution, an authority, but most centrally science means knowledge and understanding. Pseudo-science correspondingly means false claims dressed up as though they were reliable, genuine science. Denialism means refusing to believe what is unquestionably known to be true.

Knowledge means facts; understanding means theories or interpretations; and an essential adjunct to both is methodology, the means by which facts can be gathered.

There is an important connection not only between methods and facts but also between facts and theories: Un-interpreted facts carry no meaning. They are made meaningful only when connected to a conceptual framework, which is inevitably subjective. That is typically illustrated by diagrams where the facts consist of black and white lines and areas whose meaning depends on interpretations by the viewer. Different observers offer different interpretations.

The meanings of these facts — black-and-white lines and areas — are supplied by the viewer:
A young lady with extravagant hair treatment facing left — OR an old crone looking downwards;
A duck facing left OR a rabbit facing right;
Twin black profiles looking at one another OR a white vase.

In science, researchers often differ over the interpretation of the evidence: the facts are not disputed but different theories are offered to explain them.

At any rate, in considering what science can tell us we need to consider the three facets of science: facts, methods, and theories [1]. Normal scientific activity is guided by established theories and applies established methods to enlarge the range of factual knowledge.
Every now and again, something unconventional and unforeseen turns up in one of those three facets of science. It might be a new interpretation of existing facts, as in the theory of relativity; or it may be the application of a novel method as in radio-astronomy; or it may be the observation of previously unsuspected happenings, facts, for instance that atoms are not eternally stable and sometimes decompose spontaneously. When something of that sort happens, it is often referred to later as having been a scientific revolution, overturning what had been taken for granted in one facet of science while remaining content with what has been taken for granted in the other two facets.
The progress of science can be viewed as revolutions in facts, or in method followed by the gaining of possibly revolutionary facts, followed eventually by minor or major revisions of theory. Over a sufficiently long time — say, the several centuries of modern (post-17th-century) science — the impression by hindsight is of continual accumulation of facts and improvement of methods; the periodic changes in theoretical perspective are all that tends to be remembered by other than specialist historians of science.

(from “Why minority views should be listened to”)

The history of science also records episodes in which researchers proposed something novel simultaneously in two facets of science, for example when Gregor Mendel applied simple arithmetic to observations of plant breeding, an unprecedented methodology in biology that thereby uncovered entirely new facts. Another example might be the suggestion by Alfred Wegener in the early decades of the 20th century that the Earth’s continents must have moved, since the flora and fauna and geological formations are so alike on continents that are now far apart; making comparisons across oceans was an entirely novel methodology, and there was no theory to accommodate the possibility of continents moving. Episodes of that sort, where two of the three facets of science are unorthodox, have been labeled “premature science” by Gunther Stent [2]; the scientific community did not accept these suggestions for periods of several decades, until something more conventional showed that those unorthodox proposals had been sound.

When claims are made that do not fit with established theory or established methods or established facts, then those claims are typically dismissed out of hand and labeled pseudo-science. For example, claims of the existence of Loch Ness “monsters” involve unorthodox facts obtained by methods that are unorthodox in biology, namely eyewitness accounts, sonar echoes, photographs, and films, instead of the established way of certifying the existence of a species through the examination of an actual specimen; and the theory of evolution and the accepted fossil record have no place for the sort of creature that eyewitnesses describe.

In recent years it has it has been quite common see dissent from established scientific theories referred to as “denialism”. The connotation of that term “denialism” is not only that something is wrong but that it is reprehensibly wrong, that those who question the established view should know better, that it would be damaging to pay attention to them; moreover that denying (for example) that HIV causes AIDS is as morally distasteful as denying the fact of the Holocaust in which millions of Jews, Gypsies, and others were killed.

As Google N-grams for “denialism” indicate, until the last couple of decades, “denialism” meant to deny historical facts of genocide or something like it:

In the 1930s, “denialism” was applied to the refusal to acknowledge the millions of deaths in the Soviet Union caused by enforcement of collectivized agriculture and associated political purges, for example the 1932-33 Ukraine famine [3]. Holocaust denial was prominent for a while around 1970 but then faded away from mention in books until it re-appeared in the late 1980s [4]. But soon “denialism” directed at questioning of HIV/AIDS theory and the theory of carbon-dioxide-induced global warming swamped all other applications of the term:


This recent usage of “denialism” is consciously and specifically intended to arouse the moral outrage associated with denial of genocides, as admitted (for example) by the South African jurist Edwin Cameron [5]. But those genocides are facts, proved beyond doubt by the records of deaths as well as remains and various artefacts at concentration camps. By contrast, so-called “AIDS denialism” and so-called “climate-change denialism” or “global warming denialism” are the questioning or disputing of theories, not facts.

That questioning, moreover, is perfectly consonant with normal science:
⇒⇒   On the matter of whether HIV causes AIDS, dissidents do not question anything about established methods of virology, and they do not claim that HIV tests do not measure proteins, antibodies, and bits of genetic material; they merely assert that the results of HIV tests do not fit the theory that HIV is an infectious agent, and they assert that the methods used in HIV AIDS research are not sound methods for studying viruses since they have not been verified against experiments with authentic pure HIV virions derived directly from HIV+ individuals or from AIDS patients (The Case against HIV).
⇒⇒   On the matter of whether the liberation of carbon dioxide and by the burning of fossil fuels is the primary cause of global warming and climate change (AGW, Anthropogenic Global Warming and climate change [ACC]), those who question that theory do not question the facts about amounts of carbon dioxide present over time and they do not question the changes that have taken place in temperatures; they merely point out that the known and accepted facts show that there have been periods of time during which carbon-dioxide levels were very high while temperatures were very low, and that during several periods when carbon-dioxide levels were increasing the Earth’s temperature was not increasing or perhaps even cooling [6]. Furthermore, those who question AGW point out that the prime evidence offered for the theory is no evidence at all, merely the outputs of computer models that are supposed to take into account all the important variables — even as it is obvious that they do not do that, since those computer models do not provide an accurate record of the actual temperature changes that have been observed over many centuries.

Denialism means to deny something that is unquestionably true, but theories, interpretations, can never be known to be unquestionably true. Labeling as denialists those who question whether HIV causes AIDS, or those who question whether human-caused generation of carbon dioxide is the prime cause of global warming and climate change, is an attempt to finesse having to properly demonstrate the validity of those theories. Another attempt at such evasion is the oft-heard assertion that there is an “overwhelming consensus” on those matters. As Michael Crichton put it:
the claim of consensus has been the first refuge of scoundrels; it is a way to avoid debate by claiming that the matter is already settled. . . . Consensus is invoked only in situations where the science is not solid enough. Nobody says the consensus of scientists agrees that E=mc2. Nobody says the consensus is that the sun is 93 million miles away. It would never occur to anyone to speak that way [7].

When the assertion of consensus does not suffice, then the ad hominem tactic of crying “denialism” is invoked: the last refuge of intellectual scoundrels who cannot prove their case by evidence and logic.

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[1]    I first suggested this in “Velikovsky and the Loch Ness Monster: Attempts at demarcation in two controversies”, in a symposium on “The Demarcation between Science and Pseudo-Science” (ed. Rachel Laudan), published as Working Papers of the Center for the Study of Science in Society (VPI&SU), 2 (#1, April 1983) 87-106. The idea was developed further in The Enigma of Loch Ness: Making Sense of a Mystery (University of Illinois Press, 1986/88; reprint, Wipf & Stock, 2012; pp. 152-3); see also Science or Pseudoscience: Magnetic Healing, Psychic Phenomena, and Other Heterodoxies (University of Illinois Press, 2001); Science Is Not What You Think (McFarland, 2017)
[2]    Gunther Stent, “Prematurity and uniqueness in scientific discovery”, Scientific American, December 1972, pp. 84–93
[3]    Described as the Holodomor
[4]    Holocaust Denial Timeline
[5]    Edwin Cameron, Witness to AIDS, I. B. Tauris, 2005; see book review in Journal of Scientific Exploration, 20 (2006) 436-444
[6]    Climate-change facts: Temperature is not determined by carbon dioxide
[7]    Michael Crichton,  “Aliens cause global warming”, Caltech Michelin Lecture, 17 January 2003

 

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The consensus against human causation of global warming and climate change

Posted by Henry Bauer on 2018/03/18

Anthropogenic Global Warming (AGW) is the theory that global warming is caused primarily by human actions that liberate carbon dioxide and other greenhouse gases; similarly, Anthropogenic Climate Change (ACC). Proponents of AGW/ACC like to claim that 97% of climate scientists agree and that the science is settled . Both those claims are factually incorrect.

How many dissenting individuals?

Tens of thousands of scientists as well as many informed observers dispute AGW/ACC, for example in the Oregon Petition or Global Warming Petition Project: “There is no convincing scientific evidence that human release of carbon dioxide, methane, or other greenhouse gases is causing or will, in the foreseeable future, cause catastrophic heating of the Earth’s atmosphere and disruption of the Earth’s climate. Moreover, there is substantial scientific evidence that increases in atmospheric carbon dioxide produce many beneficial effects upon the natural plant and animal environments of the Earth”.

Similar points were made in the Leipzig Declaration signed by dozens of prominent scientists and television meteorologists, and in several other public statements and petitions — 1992 “Statement by atmospheric scientists on greenhouse warming” and the 1992 “Heidelberg Appeal,” circulated at the Rio de Janeiro Earth Summit (Heidelberg Appeal’s Anniversary – 4,000+ scientists, 70 Nobel Laureates).

Dissenting literature:
Scores of books and thousands of articles dispute AGW/ACC. Dunlap and Jacques list 108 such books published up to 2010 (“Climate change denial books and conservative think tanks: Exploring the connection”, American Behavioral Scientist, 57 [2013] 699–731). At least another 10 books have been published more recently, see below.

Some “1350+ peer-reviewed papers supporting skeptic arguments against ACC/AGW alarmism” are listed on-line at http://www.populartechnology.net/2009/10/peer-reviewed-papers-supporting.html.

Selected blogs:
There are innumerable blogs about AGW/ACC. In a study of arguments over how polar bears are or are not being affected, 45 pro and 45 con blogs were identified (but not named) [1].
I recommend unreservedly two blogs:

Watts Up With That (WUWT), which is notable for being centrally concerned with evidence relating to weather and climate and having no political agenda or axe to grind; Anthony Watts is a meteorologist.

Climate Etc. too has no political agenda or axe to grind. Judith Curry is a geoscientist and climatologist, recently retired after a notably distinguished career [2]. She does not deny that human activity may contribute to global warming, but shows that proponents of AGW/ACC go far beyond the evidence in raising alarms about impending catastrophes just around the corner or already here.

The actual facts:
Actual data over the life of the Earth show that CO2 levels have often been higher than now during periods when temperatures were lower. Moreover, it seems that changes in temperature occur before changes in CO2 levels and not after. Global temperatures were cooling while CO2 levels were rising during ~1880-1910 and ~1940s-1970s. Since roughly the end of the 1990s, global temperatures have not increased significantly [3]. Popular media and many proponents of AGW/ACC deny that lack of significant warming of the last couple of decades, but it is acknowledged by the National Academy of Sciences of the USA and the Royal Society of London: in a jointly published pamphlet [4] they offer excuses intended to explain why this “pause” in warming does not disprove AGW/ACC.

As against these actual data, proponents of AGW/ACC rely on computer models that are obviously and patently inadequate because they are unable to retrodict (calculate even by hindsight) the historical temperature record.

Books arguing against AGW and ACC
published since 2010 and not listed by
Dunlap & Jacques, American Behavioral Scientist, 57 (2013) 699–731

2012:    Global Warming-Alarmists, Skeptics and Deniers: A Geoscientist Looks at the Science of Climate Change, G. Dedrick Robinson &,‎ Gene D. Robinson III, Moonshine Cove Publishing

2014:    The Deliberate Corruption of Climate Science, Tim Ball, Stairway Press

2015:    Climate Change: The Facts, J. Abbot et al. (24 contributors), Stockade Books

2015:    A Disgrace to the Profession, Mark Steyn,‎ Stockade Books

2017:     Inconvenient Facts: proving Global Warming is a Hoax, Jack Madden, CreateSpace

2017:     Inconvenient Facts: The science that Al Gore doesn’t want you to know (audio book), Gregory Wrightstone, Blackstone Audio

2017:    Climate Change: The Facts, Jennifer Marohasy (ed.; 22 contributors), Connor Court Publishing

2018:    The Politically Incorrect Guide to Climate Change, Marc Morano, Regnery

2018:    The Climate Chronicles: Inconvenient Revelations You Won’t Hear from Al Gore — and Others, Joe Bastardi, CreateSpace

2018:    The Polar Blankets: The real power behind climate change, Rex Coffin, ISBN 978-1980416470 (independently published)

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[1]    “Internet blogs, polar bears, and climate-change denial by proxy”, by Jeffrey A. Harvey, by Daphne van den Berg, Jacintha Ellers, Remko Kampen, Thomas W. Crowther, Peter Roessingh, Bart Verheggen, Rascha J. M. Nuijten, Eric Post, Stephan Lewandowsky, Ian Stirling, Meena Balgopal, Steven C. Amstrup & Michael E. Mann, BioScience, bix133, https://doi.org/10.1093/biosci/bix133 (published 29 November 2017);

[2]  “Judith Curry retires, citing ‘craziness’ of climate science”, Scott Waldman, Climatewire, 4 January, 2017

[3]  “Climate-change facts: Temperature is not determined by carbon dioxide”

[4]  Climate Change: Evidence & Causes — An Overview from the Royal Society and the U.S. National Academy of Sciences, National Academies Press, 2014; see critical review, “Climate-change science or climate-change propaganda?”, Journal of Scientific Exploration, 29 (2015) 621–636

 

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Where to turn for disinterested scientific knowledge and insight?

Posted by Henry Bauer on 2018/02/11

The “vicious cycle of wrong knowledge” illustrates the dilemma we face nowadays: Where to turn for disinterested scientific knowledge and insight?

In centuries past in the intellectual West, religious authorities had offered unquestionable truth. In many parts of the world, religious authorities or political authorities still do. But in relatively emancipated, socially and politically open societies, the dilemma is inescapable. We accept that religion doesn’t have final answers on everything about the natural world, even if we accept the value of religious teachings about how we should behave as human beings. Science, it seemed, knew what religion didn’t, about the age of the Earth, about the evolution of living things, about all sorts of physical, material things. So “science” became the place to turn for reliable knowledge. We entered the Age of Science (Knight, 1983). But we (most of us) recognize that scientific knowledge cannot be absolutely and finally true because, ultimately, it rests on experience, on induction from observations, which can never be a complete reflection of the natural world; there remain always the known unknown and the unknown unknown.

Nevertheless, for practical purposes we want to be guided by the best current understanding that science can afford. The problem becomes, how to glean the best current understanding that science can offer?

Society’s knee-jerk response is to consult the scientific community: scientific associations, lauded scientists, government agencies, scientific literature. What society hears, however, is not a disinterested analysis or filtering of what those sources say, because all of them conform to whatever the contemporary “scientific consensus” happens to be. And, as earlier discussed (Dangerous knowledge II: Wrong knowledge about the history of science), that consensus is inevitably fallible, albeit the conventional wisdom is not on guard against that, largely because of misconceptions stemming from an holistic ignorance of the history of science.

The crux of the problem is that scientific knowledge and ideas that do not conform to the scientific consensus are essentially invisible in the public sphere. In any case, society has no mechanism for ensuring that what the scientific consensus holds at any given time is the most faithful, authoritative reflection of the available evidence and its logical interpretation. That represents clear and present danger as “science” is increasingly turned to for advice on public policies, in an environment replete with claims of truth from many sides, people claiming to speak for religion or for science, or organizations claiming to do so, including sophisticated advertisements by commercial and political groups.

In less politically partisan times, Congress and the administration had the benefit of the Office of Technological Assessment (OTA), founded in 1972 to provide policy makers with advice, as objective and up-to-date as possible, about technical issues; but OTA was disbanded in 1995 for reasons of partisan politics, and no substitute has been established. Society needs badly some authoritative, disinterested, non-partisan mechanism for analyzing, filtering, and interpreting scientific claims.

The only candidate so far on offer for that task is a Science Court, apparently first mooted half a century ago by Arthur Kantrowitz (1967) in the form of an “institute for scientific judgment”, soon named by others as a Science Court (Cavicchi 1993; Field 1993; Mazur 1993; Task Force 1993). Such a Court’s sole mission would be to assess the validity of conflicting contemporary scientific and technical claims and advice.

The need for such a Court is most obvious in the context of impassioned controversy in the public arena where political and ideological interests confuse and obfuscate the purely technical points, as for instance nowadays over global warming (A politically liberal global-warming skeptic?). Accordingly, a Science Court would need complete independence, for which the best available appropriate model is the United States Supreme Court. Indeed, perhaps a Science Court could be managed and supervised by the Supreme Court.

Many knotty issue beside independence present themselves in considering how a Science Court might function: choice of judges or panels or juries; choice of issues to take on; possibilities for appealing findings. For an extended discussion of such matters, see chapter 12 of Science Is Not What You Think and further sources given there. But the salient point is this:

Society needs but lacks an authoritative, disinterested, non-partisan mechanism for adjudicating conflicting scientific advice. A Science Court seems the only conceivable possibility.

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Jon R. Cavicchi, “The Science Court: A Bibliography”, RISK — Issues in Health and Safety, 4 [1993] 171–8.

Thomas G. Field, Jr., “The Science Court Is Dead; Long Live the Science Court!” RISK — Issues in Health and Safety, 4 [1993] 95–100.

Arthur Kantrowitz, “Proposal for an Institution for Scientific Judgment”, Science,
156 [1967] 763–4.

David Knight, The Age of Science, Basil Blackwell, 1986.

Allan Mazur, “The Science Court: Reminiscence and Retrospective”, RISK — Issues in Health and Safety, 4 [1993] 161–70.

Task Force of the Presidential Advisory Group on Anticipated Advances in Science and Technology, “The Science Court Experiment: An Interim Report”, RISK — Issues in Health and Safety, 4 [1993] 179–88

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Dangerous knowledge IV: The vicious cycle of wrong knowledge

Posted by Henry Bauer on 2018/02/03

Peter Duesberg, universally admired scientist, cancer researcher, and leading virologist, member of the National Academy of Sciences, recipient of a seven-year Outstanding Investigator Grant from the National Institutes of Health, was astounded when the world turned against him because he pointed to the clear fact that HIV had never been proven to cause AIDS and to the strong evidence that, indeed, no retrovirus could behave in the postulated manner.

Frederick Seitz, at one time President of the National Academy of Sciences and for some time President of Rockefeller University, became similarly non grata for pointing out that parts of an official report contradicted one another about whether human activities had been proven to be the prime cause of global warming (“A major deception on global warming”, Wall Street Journal, 12 June 1996).

A group of eminent astronomers and astrophysicists (among them Halton Arp, Hermann Bondi, Amitabha Ghosh, Thomas Gold, Jayant Narlikar) had their letter pointing to flaws in Big-Bang theory rejected by Nature.

These distinguished scientists illustrate (among many other instances involving less prominent scientists) that the scientific establishment routinely refuses to acknowledge evidence that contradicts contemporary theory, even evidence proffered by previously lauded fellow members of the elite establishment.

Society’s dangerous wrong knowledge about science includes the mistaken belief that science hews earnestly to evidence and that peer review — the behavior of scientists — includes considering new evidence as it comes in.

Not so. Refusal to consider disconfirming facts has been documented on a host of topics less prominent than AIDS or global warming: prescription drugs, Alzheimer’s disease, extinction of the dinosaurs, mechanism of smell, human settlement of the Americas, the provenance of Earth’s oil deposits, the nature of ball lightning, the evidence for cold nuclear fusion, the dangers from second-hand tobacco smoke, continental-drift theory, risks from adjuvants and preservatives in vaccines, and many more topics; see for instance Dogmatism in Science and Medicine: How Dominant Theories Monopolize Research and Stifle the Search for Truth, Jefferson (NC): McFarland 2012. And of course society’s officialdom, the conventional wisdom, the mass media, all take their cue from the scientific establishment.

The virtually universal dismissal of contradictory evidence stems from the nature of contemporary science and its role in society as the supreme arbiter of knowledge, and from the fact of widespread ignorance about the history of science, as discussed in earlier posts in this series (Dangerous knowledge; Dangerous knowledge II: Wrong knowledge about the history of science; Dangerous knowledge III: Wrong knowledge about science).

The upshot is a vicious cycle. Ignorance of history makes it seem incredible that “science” would ignore evidence, so claims to that effect on any given topic are brushed aside — because it is not known that science has ignored contrary evidence routinely. But that fact can only be recognized after noting the accumulation of individual topics on which this has happened, evidence being ignored. That’s the vicious cycle.

Wrong knowledge about science and the history of science impedes recognizing that evidence is being ignored in any given actual case. Thereby radical progress is nowadays being greatly hindered, and public policies are being misled by flawed interpretations enshrined by the scientific consensus. Society has succumbed to what President Eisenhower warned against (Farewell speech, 17 January 1961) :

in holding scientific research and discovery in respect, as we should,
we must also be alert to the equal and opposite danger
that public policy could itself become the captive
of a scientific-technological elite.

The vigorous defending of established theories and the refusal to consider contradictory evidence means that once theories have been widely enough accepted, they soon become knowledge monopolies, and support for research establishes the contemporary theory as a research cartel(“Science in the 21st Century: Knowledge Monopolies and Research Cartels”).

The presently dysfunctional circumstances have been recognized only by two quite small groups of people:

  1. Observers and critics (historians, philosophers, sociologists of science, scholars of Science & Technology Studies)
  2. Researchers whose own experiences and interests happened to cause them to come across facts that disprove generally accepted ideas — for example Duesberg, Seitz, the astronomers cited above, etc. But these researchers only recognize the unwarranted dismissal of evidence in their own specialty, not that it is a general phenomenon (see my talk, “HIV/AIDS blunder is far from unique in the annals of science and medicine” at the 2009 Oakland Conference of Rethinking AIDS; mov file can be downloaded at http://ra2009.org/program.html, but streaming from there does not work).

Such dissenting researchers find themselves progressively excluded from mainstream discourse, and that exclusion makes it increasingly unlikely that their arguments and documentation will gain attention. Moreover, frustrated by a lack of attention from mainstream entities, dissenters from a scientific consensus find themselves listened to and appreciated increasingly only by people outside the mainstream scientific community to whom the conventional wisdom also pays no attention, for instance the parapsychologists, ufologists, cryptozoologists. Such associations, and the conventional wisdom’s consequent assigning of guilt by association, then entrenches further the vicious cycle of dangerous knowledge that rests on the acceptance of contemporary scientific consensuses as not to be questioned — see chapter 2 in Dogmatism in Science and Medicine: How Dominant Theories Monopolize Research and Stifle the Search for Truth and “Good Company and Bad Company”, pp. 118-9 in Science Is Not What You Think: How It Has Changed, Why We Can’t Trust It, How It Can Be Fixed (McFarland 2017).

Posted in conflicts of interest, consensus, denialism, funding research, global warming, media flaws, peer review, resistance to discovery, science is not truth, science policy, scientific culture, scientism, scientists are human, unwarranted dogmatism in science | Tagged: , | 2 Comments »

Politics, science, and medicine

Posted by Henry Bauer on 2017/12/31

I recently posted a blog about President Trump firing members of the Presidential Advisory Council on HIV/AIDS in which I concluded with
”Above all, the sad and bitter fact is that truth-seeking does not have a political constituency, be it about HIV, AIDS, or anything else”.

That sad state of affairs, the fragile foothold that demonstrable truth has in contemporary society, is owing to a number of factors, including that “Science is broken” and the effective hegemony of political correctness (Can truth prevail?).

A consequence is that public policies are misguided about at least two issues of significant social impact: HIV/AIDS (The Case against HIV), and human-caused global warming (A politically liberal global-warming skeptic?).

Science and medicine are characterized nowadays on quite a number of matters by dogmatic adherence to views that run counter to the undisputed evidence (Dogmatism in Science and Medicine: How Dominant Theories Monopolize Research and Stifle the Search for Truth, McFarland, 2012). To cite just one absurdity (on a matter that has no significant public impact): in cosmology, the prevailing Big-Bang theory of the universe requires that “dark matter” and “dark energy” make up most of the universe, the “dark” signifying that they have never been directly observed; and there are no credible suggestions for how they might be observed directly, and nothing is known about them except that their postulated influences are needed to make Big-Bang theory comport to the facts of the real world. Moreover, a less obviously flawed theory has been available for decades, the “steady-state” theory that envisages continual creation of new matter, observational evidence for which was collected and published by Halton Arp (Qasars, Redshifts and Controversies, Interstellar Media, 1987; Seeing Red: Redshifts, Cosmology and Academic Science, Apeiron, 1998).

Dozens of books have documented what is wrong with contemporary medicine, science, and academe:
Critiques of contemporary science and academe;
What’s wrong with present-day medicine.

The common feature of all the flaws is the failure to respect the purported protocols of “the scientific method”, namely, to test hypotheses against reality and to keep testing theories against reality as new evidence comes in.

Some political commentators have described our world as “post-truth”, and a variety of social commentators have held forth for decades about a “post-modern” world. But the circumstances are not so much “post-truth” or “post-modern” as pre-Enlightenment.

So far as we know and guess, humans accepted as truth the dogmatic pronouncements of elders, shamans, priests, kings, emperors and the like until, perhaps half a millennium ago, the recourse to observable evidence began to supersede acceptance of top-down dogmatic authority. Luther set in motion the process of taking seriously what the Scriptures actually say instead of accepting interpretations from on high. The religious (Christian only) Reformation was followed by the European Enlightenment; the whittling away of political power from traditional rulers; the French Revolution; the Scientific Revolution. By and large, it became accepted, gradually, that truth is to be found by empirical means, that explanations should deal with the observed natural world, that beliefs should be tested against tangible reality.

Science, in its post-17th-century manifestation as “modern science”, came to be equated with tested truth. Stunning advances in understanding confirmed science’s ability to learn accurately about the workings of nature. Phenomena of physics and of astronomy came to be understood; then chemistry; then sub-atomic structure, relativity, quantum mechanics, biochemistry … how could the power of science be disputed?

So it has been shocking, not fully digested by any means, that “science” has become untrustworthy, as shown in the last few decades by, for instance, increasing episodes of dishonesty, fraud, unreproducible claims.

Not yet widely realized is the sea change that has overtaken science since about the middle of the 20th century, the time of World War II. It’s not the scientific method that determines science, it’s the people who are doing the research and interpreting it and using it; and the human activity of doing science has changed out of sight since the early days of modern science. In a seriously oversimplified nutshell:

The circumstances of scientific activity have changed, from about pre-WWII to nowadays, from a cottage industry of voluntarily cooperating, independent, largely disinterested ivory-tower intellectual entrepreneurs in which science was free to do its own thing, namely the unfettered seeking of truth about the natural world, to a bureaucratic corporate-industry-government behemoth in which science has been pervasively co-opted by outside interests and is not free to do its own thing because of the pervasive conflicts of interest. Influences and interests outside science now control the choices of research projects and the decisions of what to publish and what not to make public.

What science is purported to say is determined by people; actions based on what science supposedly says are chosen by people; so nowadays it is political and social forces that determine beliefs about what science says. Thus politically left-leaning people and groups acknowledge no doubt that HIV causes AIDS and that human generation of carbon dioxide is the prime forcer of climate change; whereas politically right-leaning people and groups express doubts or refuse flatly to believe those things.

For more detailed discussion of how the circumstances of science have changed, see “Three stages of modern science”; “The science bubble”; and chapter 1 in Science Is Not What You Think: How It Has Changed, Why We Can’t Trust It, How It Can Be Fixed (McFarland 2017).

For how to make science a public good again, to make science truly reflect evidence rather than being determined by political or religious ideology, see chapter 12 in Science Is Not What You Think: How It Has Changed, Why We Can’t Trust It, How It Can Be Fixed (McFarland 2017).

Posted in conflicts of interest, fraud in medicine, fraud in science, global warming, politics and science, science is not truth, science policy, scientists are human, the scientific method, unwarranted dogmatism in science | Tagged: | 1 Comment »

Can truth prevail?

Posted by Henry Bauer on 2017/10/08

Recently I joined the Heterodox Academy, whose mission is to promote viewpoint diversity :

We are a politically diverse group of social scientists, natural scientists, humanists, and other scholars who want to improve our academic disciplines and universities.
We share a concern about a growing problem: the loss or lack of “viewpoint diversity.” When nearly everyone in a field shares the same political orientation, certain ideas become orthodoxy, dissent is discouraged, and errors can go unchallenged.
To reverse this process, we have come together to advocate for a more intellectually diverse and heterodox academy.

My personal focus for quite some time has been the lack of viewpoint diversity on scientific issues — HIV/AIDS, global warming, and a host of less prominent topics (see Dogmatism in Science and Medicine: How Dominant Theories Monopolize Research and Stifle the Search for Truth). But earlier I had been appalled — and still am — over political correctness, by which I mean the dogmatic assertion that certain sociopolitical views must not only prevail but must be enforced, including by government action.

I became aware of political correctness when it came to my university in the late 1980s (distinctly later than elsewhere) and led to the resignation of Alan Mandelstamm, a nationally renowned teacher (of economics) who had for more than a decade attracted more students to his classes than any other teacher of any subject, as well as having a variety of faculty members from other fields sit in on his classes purely for the learning experience. I’ve described the circumstances of Al’s resignation in a couple of articles (The trivialization of sexual harassment: Lessons from the Mandelstamm Case; Affirmative action at Virginia Tech: The tail that wagged the dog). Al passed away some years ago; his obituary has been funded to be permanent and the contributors to it testify to what a marvelous instructor Al was, to the benefit of untold numbers of individuals: 4 years after Al died, former students and associates who learn of his passing continue to add their recollections. Al and I had both participated in the Virginia chapter of the National Association of Scholars (NAS), which stands for traditional academic ideals:
NAS is concerned with many issues, including academic content, cost, unfairness, academic integrity, campus culture, attitudes, governance, and long-term trends. We encourage commitment to high intellectual standards, individual merit, institutional integrity, good governance, and sound public policy.

What that involves in practice is illustrated in the newsletter I edited until my retirement.

Common to NAS, the Heterodox Academy, and dissenting from dogmatism on HIV/AIDS, global warming, and many other issues is the belief that views and actions ought to be consonant with and indeed formed by the available evidence and logical inferences from it — by the truth, in other words, at least as close as humans can come to it at any given time.

Ideologies and worldviews can make it difficult for us even to acknowledge what the evidence is when it seems incompatible with our beliefs. Since my interest for many decades has been in unorthodoxies, I’ve looked into the evidence pertaining to a greater number of controversial issues, in more detail and depth, than most people have had occasion to, with the frustrating consequence that nowadays many of the people with whom I share the preponderance of sociopolitical preferences are not with me regarding HIV/AIDS or global warming; I’m the rare example of “A politically liberal global-warming skeptic”; and I wish that those who seem to agree with me did not include people whose sociopolitical views and actions are abhorrent to me (say, Ted Cruz or Jeff Sessions).

At any rate, in science and in the humanities and in politics, in all aspects of human life, the thing to aim for is to find the best evidence and to be guided by it. Through the Heterodox Academy I learned recently of the Pro-Truth Pledge; see “How to address the epidemic of lies in politics: The ‘Pro-Truth Pledge,’ based on behavioral science research, could be part of the answer”.

The badge of that pledge is now on my personal website, and I encourage others to join this venture.

 

I don’t expect quick results, of course, but “The journey of a thousand miles begins with one step” (often misattributed to Chairman Mao, but traceable more than a millennium further back to Lao Tzu or Laozi, founder of Taoism).

Posted in conflicts of interest, consensus, global warming, politics and science, science is not truth, science policy, scientific culture, scientists are human, unwarranted dogmatism in science | Tagged: , , , , | Leave a Comment »

Slowing of global warming officially confirmed — by reading between the lines

Posted by Henry Bauer on 2017/08/12

Climate-change skeptics, deniers, denialists, and also unbiased observers have pointed out that measured global temperatures seem to have risen at a slower rate, or perhaps ceased rising at all, since about 1998.
But the media have by and large reported the continuing official alarmist claims that each year has been the hottest on record, that a tipping point is nearly upon us, catastrophe is just around the corner — exemplified perhaps by Al Gore’s recent new film, An Inconvenient Sequel, with interviews of Gore in many media outlets.

However, that the pause in global warming is quite real is shown decisively by the way in which the mainstream consensus has tried to discount the facts, attempting to explain them away.
For example a pamphlet, published jointly by the Royal Society of London and the National Academy of Sciences of the USA, asserts that human-caused release of greenhouse gases is producing long-term warming and climate change, albeit there might be periods on the order of decades where there is no or little warming, as with the period since about 2000 when such natural causes as “lower solar activity and volcanic eruptions” have “masked” the rise in temperature (“Climate-Change Science or Climate-Change Propaganda?”).

That assertion misses the essential point: All the alarmist projections are based on computer models. The models failed to foresee the pause in temperature rise since 1998, demonstrating that the models are inadequate and therefore their projections are wrong. The models also fail to accommodate the period of global cooling rather than warming from the 1940s to the 1970s.

The crux is that the models do not incorporate important natural forces that affect the carbon cycle and the energy interactions. Instead, when the models are patently wrong, as from 1940s to 1970s and since 1998, the modelers and other researchers vested in the theory of human-caused climate change speculate about how one or other natural phenomenon somehow “masks” the asserted underlying temperature rise.

Above all, of course, the theorists neglect to mention that the Earth is still rebounding from the last Ice Age and will, if the last million years are any guide, continue to warm up for many tens of thousands of years (Climate-change facts: Temperature is not determined by carbon dioxide).
The various attempts to explain away the present pause in temperature rise were listed a few years ago at THE HOCKEY SCHTICK“Updated list of 66 excuses for the 18-26 year ‘pause’ in global warming — ‘If you can’t explain the ‘pause’, you can’t explain the cause’”.
Here are a few of the dozens of excuses for the failure of global temperature to keep up with projections of the climate models:

1. Lower activity of the sun
That ought to raise eyebrows about this whole business. Essentially all the energy Earth receives from out there comes from the Sun. Apparently the computer models do not start by taking that into account?
(Peter Stauning, “Reduced solar activity disguises global temperature rise”, Atmospheric and Climate Sciences, 4 #1, January 2014 “Without the reduction in the solar activity-related contributions the global temperatures would have increased steadily from 1980 to present”)
And of course if the Sun stopped shining altogether…
Anyway, the models are wrong.

2. The heat is being hidden in the ocean depths (Cheng et al., “Improved estimates of ocean heat content from 1960 to 2015”, Science Advances, 10 March 2017, 3 #3, e1601545, DOI: 10.1126/sciadv.160154
In other words, the models are wrong about the distribution of supposedly trapped heat.

3. Increased emission of aerosols especially in Asia (Kühn et al., “Climate impacts of changing aerosol emissions since 1996”, Geophysical Research Letters, 41 [14 July 2014] 4711–18, doi:10.1002/2014GL060349)
The climate models are wrong because they do not properly take aerosol emissions into account.

3a. “Volcanic aerosols, not pollutants, tamped down recent Earth warming, says CU study”
       In other words, the models are wrong because they cannot take into account the complexities of natural events that affect climate.

4. Reduced emission of greenhouse gases, following the Montreal Protocol eliminating ozone-depleting substances (Estrada et al, “Statistically derived contributions of diverse human influences to twentieth-century temperature changes”, Nature Geoscience, 6 (2013) 1050-55 doi:10.1038/ngeo1999
       The climate models are wrong because they do not take into account all greenhouse-gas emissions.

5. “Contributions of stratospheric water vapor to decadal changes in the rate of global warming” (Solomon et al., Science, 327 [2010] 1219-12;
DOI: 10.1126/science.1182488)
In other words, the models are wrong because they do not take account of variations in water vapor in the stratosphere.

6. Strengthened trade winds in the Pacific
Again, the models are wrong because they cannot take account of the innumerable natural phenomena that determine climate.

6a.     An amusing corollary is that “Seven years ago, we were told the opposite of what the new Matthew England paper says: slower (not faster) trade winds caused ‘the pause’”

And so on though another 50 or 60 different speculations. Although they are all different, there is a single commonality: The computer models used to represent Earth’s climate are woefully unable to do so. That might well be thought to be obvious a priori in view of the astronomical number of variables and interactions that determine climate. Moreover, a little less obviously perhaps, “global” climate is a human concept. The reality is that short- and long-term changes in climate by no means always occur in parallel in different regions.

Take-away points:

Mainstream climate science has demonstrated that
all the climate models are inadequate
and their projections have been wrong

Since the late 1990s, global temperatures have not risen
to the degree anticipated by climate models and climate alarmists
but that is not officially admitted
even as it is obvious from the excuses offered
for the failure of the models

Posted in consensus, denialism, global warming, media flaws, science is not truth, science policy, unwarranted dogmatism in science | Tagged: | 3 Comments »

Another medical dogma deconstructed: DO NOT restrict sodium intake

Posted by Henry Bauer on 2017/08/01

Medical dogma has long been that blood pressure should be lowered to a level that is normal for young people, and that taking in salt increases blood pressure significantly.

The facts are otherwise. Lowering salt intake has a virtually negligible effect in lowering blood pressure, but low sodium causes tangible harm: Rethinking the War on Salt

The book-length discussion is The Salt Fix.

Posted in consensus, medical practices, science policy, unwarranted dogmatism in science | Tagged: | Leave a Comment »

HPV vaccines: risks exceed benefits

Posted by Henry Bauer on 2017/07/09

“Vaccination” is publicly argued in black/white, yes/no fashion, as though one had to be either for or against ALL vaccinations. But the fact is that the benefits of some vaccinations far outweigh the dangers of occasional harmful “side” effects whereas that is not clear with other vaccines. Polio vaccine, for example, seems to have been wonderfully effective and is still so in many countries; on the other hand, in regions where polio is no longer endemic, the risk of contracting polio from oral vaccine exceeds the danger of contracting it when not vaccinated (see links near the end of What to believe? Science is a red herring and a wild-goose chase).

Immune systems are complex and not fully understood, and there are individual variations galore — as when one of my friends came down with shingles shortly after being vaccinated against shingles. (The doctor of course assured him that the outbreak would have been more painful had he not been vaccinated; an ex cathedra assertion without possibility of verification.)

I was reminded of the issue of HPV vaccination by a brouhaha in Europe between the European Medicines Agency (EMA) and medical practitioners and researchers who had come across a substantial number of cases of harm seemingly following HPV vaccination, harm specifically in the form of chronic autoimmune ailments. Since vaccination affects the immune system, such an undesired effect in some individuals seems perfectly plausible.

The Nordic Cochrane Center exists for the purpose of evaluating the evidence underlying medical practices. The Cochrane Center and others have been campaigning for many years to have the data from clinical trials made available to all researchers (1). Last year it lodged a complaint (2) against EMA for conflicts of interest with drug companies exacerbated by the secrecy of discussions that led to criticism of physicians’ reports about autoimmune symptoms appearing after vaccination against HPV. That secrecy is truly extraordinary, virtually an admission of conspiracy: “experts who are involved in the process are not named and are bound by lifelong secrecy about what was discussed” (3).

An EMA publication had severely criticized publications by Louise Brinth and others who had published reports of autoimmune symptoms following vaccination (4); Brinth has delivered a blistering response to the EMA insinuations (5).

The supposed benefit of vaccinating against HPV is to decrease the risk of certain cancers, primarily of the cervix. There are perhaps a hundred types of HPV, of which about 40 are sexually transmitted, and two to four of these seem to be statistically correlated with cancer:
“High-risk HPV strains include HPV 16 and 18 . . . . Other high-risk HPV viruses include 31, 33, 45, 52, 58, and a few others. Low-risk HPV strains, such as HPV 6 and 11, cause about 90% of genital warts, which rarely develop into cancer” (What is HPV?).

HPV infections are the most common sexually transmitted infection: “HPV is so common that nearly all sexually active men and women get the virus at some point in their lives” (Human Papillomavirus (HPV) Statistics). Thus most infections do not lead to cancer, which might induce thought about what “cause” could mean in this context. About 4% of Americans are infected each year with a “high-risk” strain, about 6 million women (USA population is about 320 million, so roughly 160 million women). There are only about 12,000 cases annually of cervical cancer: thus only about 1 in 500 of even “high-risk” infections is associated with this cancer. Thus vaccinating about 500 “high-risk” women might prevent 1 cervical cancer; NNT (number needed to be treated for 1 person to benefit) = 500.

On the other hand, there appears to be about 1 chance in 200 of an adverse effect from vaccination by Gardasil (Gardasil and the sad state of present-day medical practices); about 8% (~ 1 in 12) of adverse events are “serious”, so there’s about 1 chance in 2500 of a serious adverse event. NNH (number needed to be treated for one person to be seriously harmed) = 2500.

For any medical treatment to be desirable, it should be necessary to treat many more people to harm a single one than the number needed to be treated to benefit a single person; NNH should exceed NNT by a substantial amount.
The numbers just mentioned yield a ratio of only 5 — in other words, there’s something like a 1 in 5 chance, 20%, that HPV vaccination would harm rather than benefit. But those numbers apply if only those women infected with high-risk strains are vaccinated. However, the advocates of HPV vaccination, which includes official agencies in the USA and some other countries, recommend HPV vaccination for all girls. That increases NNT by a factor of 25 and reverses drastically the benefit/cost ratio: It is 5 times more likely that an HPV vaccination will result in a serious adverse event than that the vaccination prevents a case of cervical cancer — even if HPV is the actual cause of cervical cancer, which remains to be proved beyond a mere weak statistical correlation.

It is simply not known whether HPV causes cancer at all. Certainly it does not always cause cancer. An extended article on the invaluable Snopes.com website that debunks urban legends is judicious on this matter by pointing out that the claimed association of HPV vaccination with autoimmune symptoms is only speculative. On the other hand, it also concludes in an update of 12 June 2017:
“An earlier version of this story incorrectly stated that countries with high HPV vaccination rates show declines in cervical cancer diagnoses. Both Gardasil and Cervarix have demonstrated efficacy in preventing HPV infections that cause cervical cancer, and evidence suggests declines in precancerous lesions and other abnormal growths as a result of HPV vaccination. There is debate over evidence for declines in cervical cancer diagnoses — as well as over how much time it would take after the introduction of the vaccine to see any effect on cancer diagnoses” [italics added].

The vaccines against HPV are successful against HPV — but it has never been proved that HPV (or the four strains of it supposed to be associated with cervical cancer) actually causes cancer. Since the rate of HPV infections exceeds the rate of cervical cancer by a huge amount, any “causative” action of HPV must be very indirect, especially since only a small percentage of HPV strains shows even a statistical association with cancer.
Recall that the usual test of “statistical significance” in medicine is p ≤ 0.05, meaning that there is less than a 5% chance that the association is owing only to chance. If there are 100 possible associations, about 5 of them will seem significant even though they are not, being picked out purely by chance because of the (weak!) criterion for statistical significance (6). If there are 100 strains of HPV, then at p ≤ 0.05, purely by chance about 5 strains will seem to be correlated with cervical cancer — or with just about anything else.
Before accepting any role fort HPV in cervical cancer, one should want a demonstration of the mechanism of the claimed causative effect.

***************************************
(1) “Opening up data at the European Medicine”, Peter Gøtzsche & Anders Jørgensen, British Medical Journal, 342 (28 MAY 2011) 1184-6; “EMA must improve the quality of its clinical trial reports”, Corrado Barbui , Cinzia Baschirotto & Andrea Cipriani, ibid., 1187-9
(2) Complaint to the European Medicines Agency (EMA) over maladministration at the EMA, 26 May 2016
(3) “Complaint filed over EMA’s handling of HPV Vaccine safety issues”, Zosia Chustecka, 5 July 2016
(4) “Suspected side effects to the quadrivalent human papilloma vaccine”, Louise Brinth, Ann Cathrine Theibel1, Kirsten Pors & Jesper Mehlsen, Danish Medical Journal, 62 (#4, 2015) A5064
(5) “Responsum to Assessment Report on HPV-vaccines released by EMA November 26th 2015” by Louise Brinth, MD PhD, Syncope Unit, Bispebjerg and Frederiksberg Hospital, Copenhagen, December 15th 2015
(6) For a thorough discussion of the pitfalls of interpreting p values, see Gerd Gigerenzer, “Mindless Statistics”, Journal of Socio-Economics, 33 (2004) 587-606.

Posted in medical practices, prescription drugs, science policy, unwarranted dogmatism in science | Tagged: , , | 2 Comments »

 
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